Infant gut microbiome shows resilience against mode of delivery but is susceptible to feed type


  • Nabeel Khan University of British Columbia
  • Soomin Lee
  • Brandon Wong
  • Helen Xu


As cesarean section and formula feeding become increasingly popular, it is important to examine how mode of delivery and diet influence the development and composition of the infant gut microbiome. Awareness of the factors that influence an infant’s gut flora could help improve their short- and long-term health outcomes. With this in mind, here we investigate the influence of delivery and feeding method on the early infant gut microbiome; specifically, how vaginal versus cesarean section birth, and breastfeeding versus formula feeding impact gut flora. Additionally, we attempt to determine whether the type of feed and the method of delivery impact the vertical transmission of gut bacteria from mother to infant, and how the infant microbiome composition changes over time. We are able to show that breastfed and formula-fed infants had similar gut community richness but differed in microbial community composition at 6 months of age. Microbes belonging to the Veillonellaceae and Pasteurellaceae families were found to be more abundant in the gut microbiomes of breastfed infants, whereas microbes belonging to the Lachnospiraceae family were more abundant in formula-fed infants. Infants delivered via cesarean section and vaginal modes did not significantly differ in community richness and microbiome composition at 0.5 months of age. Microbes from the Lachnospiraceae family were found to be more abundant in the gut microbiomes of the cesarean section infants. All infant groups (cesarean section, vaginally delivered, breastfed and formula-fed infants) maintained stable community differences from their mothers over the 6-month period tested.


Additional Files