Metaplasticity: A New Frontier in the Neural Representation of Memory
Modification of the strength of connections between neurons is widely accepted to be essential for information storage in the brain and thus form the basis of learning and memory. However, many regulatory mechanisms must exist in order for the richness of learning and memory to emerge from the simple long-term potentiation and depression of synapses. Metaplasticity, the regulation of synaptic plasticity by prior history of synaptic activity, is a newly discovered phenomenon which offers a deeper understanding of how synaptic plasticity is able to occur within an effective dynamic range and result in meaningful, coordinated changes in neural activity. A complete understanding of the mechanisms of plasticity and metaplasticity would not only be valuable for clinical application, but provide a link between the fields of biology, psychology, and cognitive science.
Authors who publish with this journal agree to the following terms:
(1)Being an open access journal, UBCUJP will apply the Creative Commons Attribution-NonCommercial-NoDerivatives License http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode, to all published works. Under this license, authors retain ownership and copyright to their article, but allow anyone to download and share articles in the UBCUJP, so long as the original author(s) and sources are cited and the works are not used for commercial purposes or altered in any way;
(2)The Author(s) grant the UBCUJP the right of first and exclusive distribution of the published work in print and/or online. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of UBCUJP’s published version of their work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in UBCUJP;
(3)The Author(s) warrant that permission to publish the article has not been previously assigned elsewhere;
(4)The Author(s) warrant that the contribution is original to them, except for any copyrighted material of others incorporated in it, and that the Author(s) will advise us of any material, either text or illustration or graphical, the rights for which are controlled by others. Where necessary, the Author(s) will obtain, before publication and at their expense, permission in writing from the owner of the copyright in that material for publication by us.