Dissolution Efficacy of Various Advil Pill Forms in Gastric Acid-like Conditions


  • Carvalho MacDonald A
  • Filewych M
  • Nalliah S
  • Rivera J


Pills come in many shapes and sizes, and with various coatings. Some are powder caplets
or tablets with thin sugar coatings, while others contain liquid inside a gel (Brookshire, 2017).
These alterations may play a role in how quickly a pill is broken down and absorbed into the
bloodstream (Brookshire, 2017). Speed is one of the greatest consumer desired benefits for
relieving symptoms and many Advil pills claim to have fast and effective pain relief (GSK
group, 2017). This experiment examined the dissolving efficacy of four types of Advil pills;
Advil tablets, Advil caplets, Advil Liqui-Gels, and Advil Mini-Gels. The time taken to dissolve
was examined at pHs 2, 3 and 7 using lemon juice (n=3), orange juice (n=3), and water (n=1),
respectively, for each pill type. The acidic pHs were chosen to simulate gastric acid and
breakdown in the stomach, while pH 7 served as a control. Our results concluded that Advil
Liqui-Gel pills take a significantly longer time to dissolve at all tested pHs in comparison to the
three other pill types, which took similar amounts of time.