Regulating hypoxic behaviour in solid tumors
DOI:
https://doi.org/10.14288/cjur.v9i1.198763Abstract
Adaptation to hypoxic environments allows malignant tumors to outcompete normal cells. This microenvironment increases treatment resistance and favours tumor progression. However, certain cellular responses can be anti-tumorigenic. Understanding and utilizing oxygen dependent pathways like hypoxia-induced factors (HIF) can enhance therapy efficacy for different types of cancer by regulating glycolysis, metastasis, and immune invasion. This article focuses on the HIF pathway, eukaryotic elongation factor kinase (eEFK2) stabilization, protein disulfide isomerases (PDIs), and the immune response to hypoxia. These four key components bridge hypoxic stress and cancer, highlighting their potential therapeutic implications.
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