ApoA-I deficiency has a subtle effect on acute inflammatory responses after experimental Traumatic Brain Injury
Cerebral vascular injury is a common phenomenon after traumatic brain injury (TBI), with complications including vascular inflammation, decreased cerebral blood flow, and increased vessel tortuosity following TBI. Promoting cerebrovascular health may therefore be a useful therapeutic intervention after TBI. High density lipoproteins (HDL) are an attractive target due to their vasoprotective and anti-inflammatory roles in periphery vessels, but little is known on whether these benefits extend to the brain. Recently, deficiency of ApoA-I, the major protein constituent of circulating HDL, was shown to increase vascular associated plaque load in Alzheimer’s Disease (AD) mice, which may imply a vessel protective function of ApoA-I in the brain. This study was designed to test the novel hypothesis that ApoA-I deficiency would worsen acute vascular and inflammatory outcomes in mice after Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) TBI. ApoA-I KO and WT mice underwent single moderate-severe TBI. Histopathological outcomes at 6hr and 2 days (2D) post injury were assessed. ApoA-I deficient mice exhibited greater ICAM-1 immunoreactivity at the cortex at 2D post TBI compared to WT controls, and a subtle increase in brain cytokine levels, potentially suggesting role of ApoA-I in protecting from TBI induced inflammation.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).