Effect of isoamyl alcohol on aggregation of wild-type and mutant Caenorhabditis elegans

Brayden N. Eagles, Michelle Kim, Dixon W. Leroux, Nicole M. Ly


Caenorhabditis elegans respond to chemical stimuli through olfaction involving transfer of chemical signals via synapses to produce an elicited response which results in moving towards, away, or producing a neutral response to the chemical stimuli (Bargmann 2006). Using isoamyl alcohol as an attractant, both mutant C. elegans and wild type were exposed for a set amount of time and aggregation was observed after 30 minutes. Isoamyl alcohol was found to affect the aggregation of C. elegans when compared to control conditions (p=0.0005), the aggregation of the mutant phenotype was different than wild type (p=0.0051), and both the wild type and mutant responded differently to the attractant (p=0.0051). It is suggested that unc-2 regulating odorant receptor gene str-2 explains the mutant’s minimal response to attractant.

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